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KMID : 0363220120500110994
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Korean Journal of Dermatology
2012 Volume.50 No. 11 p.994 ~ p.997
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Ulcerative Necrobiosis Lipoidica Improved by Hydroxychloroquine
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Son Hyun-Ho
Kwon Tae-Gwang
Shim Hyun-Soo
Lee Sook-Kyung
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Abstract
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Necrobiosis lipoidica (NL) is a chronic granulomatous skin disease of unknown etiology, which can be seen in patients with diabetes mellitus. Typical lesions of NL appear on the pretibial skin as painful yellow-brown inflammatory plaques with raised borders and atrophic centers. Ulceration occurs in approximately 35% of cases, leading to increased risk of secondary bacterial infection and scarring. Although there have been many proposed therapies for ulcerative NL, the response to treatment is often met with limited success. Here, we report a case of a 19-year-old girl with ulcerative NL, which showed improvements with oral hydroxychloroquine, an antimalarial agent.
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KEYWORD
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Hydrochloroquine, Ulcerative necrobiosis lipoidica
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